Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Patel, Kalpana G.
- Development and Evaluation of Robust RP-HPLC Method for Gliclazide Estimation Integrating Box Behnken Design
Abstract Views :148 |
PDF Views:0
Authors
Mansi S. Dholakia
1,
Hardik B. Rana
2,
Saloni Desai
2,
Mukesh C. Gohel
2,
Kalpana G. Patel
2,
Vaishali T. Thakkar
2,
Tejal R. Gandhi
2
Affiliations
1 Dharamsinh Desai University, Nadiad- 387001, Gujarat, IN
2 Department of Pharmaceutics, Anand Pharmacy College, Anand - 388 001, Gujarat, IN
1 Dharamsinh Desai University, Nadiad- 387001, Gujarat, IN
2 Department of Pharmaceutics, Anand Pharmacy College, Anand - 388 001, Gujarat, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 135-141Abstract
A selective, precise and accurate RP-HPLC method was developed and validated for rapidly determining the quantity of gliclazide in pharmaceutical dosage form. Isocratic elution was employed on a PhenomenexC18 column at a flow rate of 1.2 ml/min. The mobile phase consisted of methanol and 0.02 M potassium dihydrogen orthophosphate (70:30 %v/v). Gliclazide was detected at 210 nm wavelength using UV detector. Linearity was observed in concentration range of 1-100 μg/ml. Retention time of gliclazide retention time was found to be 6.06 min. Validation of developed method was performed as per the ICH guideline. Experimental design approach was used for confirmation of robustness by using Box-Behnken Design with a total 17 runs. The newer method is found to be promising for the estimation of gliclazide in unit or bulk pharmaceutical dosage form.Keywords
Gliclazide, RP-HPLC, Validation, Box-Behnken Design, Robustness.
References
- Sola D, Rossi L, Schianca GPC, Maffioli P, Bigliocca M, Mella R, et al. Sulfonylureas and their use in clinical practice. Arch Med Sci. 2015;11(4):840–8.
- Harrower ADB. Efficacy of gliclazide in comparison with other sulphonylureas in the treatment of NIDDM. Diabetes Res Clin Pract. 1991;14(SUPPL. 2):65–7.
- Resztak M, Hermann TW, Sawicki W, Danielak DZ. Pharmacokinetics and pharmacodynamics of gliclazide from immediate and modified release formulation tablets in rats. Iran J Pharm Res. 2014;13(1):29–37.
- Tripathi KD. Essentials of Medical Pharmacology. 5th Editio. Jaypee Brothers Medical Publishers (P) Ltd.; 2004. 245-253 p.
- Varma MM, Kumar PS. Formulation and Evaluation of Gliclazide Tablets Containing PVP-K30 and Hydroxypropyl-β-cyclodextrin Solid Dispersion. Int J Pharm Sci Nanotechnol. 2012;5(2):1706–19.
- United State Pharmacopoeia, USP 35 NF 30. Vol. II. Rockville, MD: United State Pharmacopoeial Commission; 2012. 1551 p.
- Dhabale PN, Seervi CR. Simultaneous UV spectrophotometric method for estimation of gliclazide and metformine hydrochloride in tablet dosage form. Int J ChemTech Res. 2010;2(2):813–7.
- Bhanu R, Kulkarni S, Kadam A. Simultaneous estimation of guclazide and metformin in pharmaceutical dosage by reverse phase high performance liquid chromatography. Indian drugs. 2006;43(1):16–20.
- Ghai D, Gorle LG. HPLC Method for Determination of Gliclazide in Human Serum. Asian J Chem. 2009;21(6):4258–64.
- Brunton L, Chabner B, Knollman B. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. In: Journal of Chemical Information and Modeling. 12th ed. New Delhi: Mcgraw-Hill medical publishing division; 2006. p. 1634–9.
- Talar R, Arshosaz J, Mostafavi A, Nokhodchi A. Development and validation of a novel rp-hplc method for pharmacokinetic studies of gliclazide in rat. Farmacia. 2011;59(3):388–95.
- Packianather M, Chan F, Griffiths C, Dimov S, Pham DT. Optimisation of micro injection moulding process through design of experiments. Procedia CIRP [Internet]. 2013;12:300–5. Available from: http://dx.doi.org/10.1016/j.procir.2013.09.052
- Costa-Machado ARM, Bastos JK, de Freitas LAP. Dynamic maceration of Copaifera langsdorffii leaves: A technological study using fractional factorial design. Brazilian J Pharmacogn. 2013;23(1):79–85.
- Inglot T. New HPLC Method with Experimental Design and Fluorescence Detection for Analytical Study of Antihypertensive Mixture, Amlodipine and Valsartan. Am J Anal Chem [Internet]. 2013;4(1):17–23. Available from: http://www.scirp.org/journal/PaperDownload.aspx?DOI=10.4236/ajac.2013.41003
- ICH Topic Q2 (R1) Validation of Analytical Procedures : Text and Methodology. Int Conf Harmon. 2005;1–17.
- Gangishetty, S., and Verma, S. RP-HPLC Method Development and Validation for Simultaneous Estimation of Clarithromycin and Paracetamol. ISRN Anal Chem. 2013;2013(5):1–6.
- Vaingankar PN, Amin PD. Development and Validation of StabilityIndicating RP-HPLC Method for Simultaneous Determination of Metformin HCI and Glimepiride in Fixed-Dose Combination. Anal Chem Insights [Internet]. 2016;11:13–20. Available from: http://journals.sagepub.com/doi/10.4137/ACI.S38137
- Jančic Stojanovic B, Rakić T, Slavković B, Kostić N, Vemić A, Malenović A. Systematical approach in evaluation of LC method for determination of raloxifene hydrochloride and its impurities employing experimental design. J Pharm Anal. 2013;3(1):45–52.
- Thakur D, Kaur A, Sharma S. Application of QbD based approach in method development of RP-HPLC for simultaneous estimation of antidiabetic drugs in pharmaceutical dosage form. J Pharm Investig. 2017;47(3):229–39.
- Thumar PM, Patel VB. Development and Validation of Analytical method for estimation OF Balofloxacin in Bulk and Pharmaceutical dosage form. 2011;3(4):1938–41.
- Mens R, Adriaensens P, Foreman P, Gelan J, Paul J, Vervaet C. Development of starch-based pellets via extrusion / spheronisation. 2007;66:83–94.
- Mittal A, Imam SS, Parmar S GS and TM. Design of Experiment based Optimized RP-HPLC Method for Simultaneous Estimation of Amlodipine and Valsartan in Bulk and Tablet Formulations. Austin J Anal Pharm Chem [Internet]. 2015;2(6):1–6. Available from: file:///C:/Users/Administrator/Downloads/fulltext-ajapc-v2-id1057.pdf
- Dash RN, Mohammed H, Humaira T. An integrated Taguchi and response surface methodological approach for the optimization of an HPLC method to determine glimepiride in a supersaturatable selfnanoemulsifying formulation. Saudi Pharm J [Internet]. 2016;24(1):92–103. Available from: http://dx.doi.org/10.1016/j.jsps.2015.03.004
- Ajitha M, Pranathi K. Simultaneous method development and validation of chromium Picolinate and Metformin by using RP-HPLC in its bulk. J Sci Res Pharm [Internet]. 2017;1–9. Available from: http://www.jsrponline.com/Archives_html.php?htmlcode=543
- Kalariya PD, Namdev D, Srinivas R, Gananadhamu S. Application of experimental design and response surface technique for selecting the optimum RP-HPLC conditions for the determination of moxifloxacin HCl and ketorolac tromethamine in eye drops. J Saudi Chem Soc [Internet]. 2017;21:S373–82. Available from: http://dx.doi.org/10.1016/j.jscs.2014.04.004
- Ganorkar SB, Dhumal DM, Shirkhedkar AA. Development and validation of simple RP-HPLC-PDA analytical protocol for zileuton assisted with Design of Experiments for robustness determination. Arab J Chem [Internet]. 2017;10(2):273–82. Available from: http://dx.doi.org/10.1016/j.arabjc.2014.03.009
- Ravikumar B, Patnaik A, Raul S, Rao N. RP-HPLC Method Development and Validation for the Estimation of Baclofen in Bulk and Pharmaceutical Dosage Forms. J Appl Pharm Sci [Internet]. 2013;3(4):59–62. Available from: www.sadgurupublications.com